Web6 Apr 2024 · Microglia are the resident immune cells of the central nervous system. They constantly survey the brain parenchyma for redundant synapses, debris or dying cells, … Web12 Feb 2024 · Microglia exhibit multiple, phenotype-dependent motility patterns often triggered by purinergic stimuli. However, little data exist on motility of human microglia in pathological situations. ... THIK1, contribute to surveillance movements but not process extension (Madry et al., 2024). Akt, a Ca-dependent kinase, activates beta1 integrins ...
Effect of THIK-1 Knockout on Microglial Surveillance, …
Web16 Aug 2024 · Mechanistically, we revealed that the SUR1-TRPM4 complex served as a K + efflux amplifier in activating the NLRP3 inflammasome in microglia, via mediating Na + influx, contributing to the depolarized membrane potential, and thereby gating downstream K + channels. Materials and Methods Animals Web11 Sep 2024 · Given that THIK1 is also required for the release of IL-1β by microglia, this finding may have therapeutic implications: these may include stimulation of THIK1 … downloadable publisher
Role of Microglia in Ataxias. - Abstract - Europe PMC
WebTHIK-1 controls key microglial function across the spectrum including surveillance, ramification, phagocytosis and membrane voltage (Izquierdo et al., 2024;Madry et al., … Web12 Apr 2024 · Our efficient and rigorous peer review means you’ll get a decision on your manuscript in just 77 days. Publishing fees Article processing charges (APCs) apply to articles that are accepted for … Web17 Jan 2024 · THIK-1 is tonically active, and its activity is potentiated by P2Y12receptors. Inhibiting THIK-1 function pharmacologically or by gene knockout depolarizes microglia, which decreases microglial ramification and thus reduces surveillance, whereas blocking P2Y12receptors does not affect membrane potential, ramification, or surveillance. clarence jones oakfield maine