Oocyte meiotic spindle assembly and function
Web20 de dez. de 2024 · Background ADD1 (adducin-1) and TPX2 (targeting protein for Xklp2) are centrosomal proteins and regulate mitotic spindle assembly. Mammalian oocytes that segregate homologous chromosomes in Meiosis I and sister chromatids in Meiosis II with a spindle lacking centrosomes are more prone to chromosome segregation errors than in … Web23 de jan. de 2016 · Systematic investigations of how microtubule-kinetochore attachments, and kinetochore function more generally, influence spindle assembly and …
Oocyte meiotic spindle assembly and function
Did you know?
WebHere, we show that Cdc42, a key regulator of cytoskeleton and cell polarity in other systems , is essential for meiotic maturation and oocyte asymmetry. Disrupting CDC42 function … WebHá 1 hora · Left indicates representative oocyte with zero univalents. Right indicates representative oocyte with ... him-3 R93Y and htp-1 G97T mutants have functional …
Web1 de jan. de 2016 · The assembly of the microtubule-based spindle structure that mediates this reduction in genome content remains poorly understood compared … WebWe show that KLP-7, the single mitotic centromere-associated kinesin (MCAK)/kinesin-13 in Caenorhabditis elegans, is required for bipolar …
Web13 de nov. de 2012 · The microtubule-associated protein ASPM (abnormal spindle-like microcephaly-associated) plays an important role in spindle organization and cell … Web28 de mai. de 2024 · Blocking CPSF function in mouse oocytes leads to impaired meiotic spindle assembly and PB1 emission. These phenotypes resemble those observed following blockade of PAPα in the current study. These results indicate that the interaction between PAPα and CPSF has a significant role in oocyte meiotic maturation.
WebThe meiotic spindle is the major structure involved with the segregation of chromosomes at anaphase of meiosis one and meiosis 2 (Figure 2.15 ). Invariably, the spindle is anchored to the oocyte cortex and deploys centrosome proteins at the spindle poles.
WebIts structure and function mediate the mechanical alignment and segregation of chromosomes during MI and MII. Errors in these processes, as well as defects in the assembly and disassembly of the spindle microtubule structure, increase the risk of aneuploid gametes (6, 9, 10). The oocyte meiotic spindle can be noninvasively visual- javascript resize svgWeb13 de abr. de 2024 · For example, oocyte quality, embryonic development, and fertility can be restored by nicotinamide mononucleotide treatment in aged mice . Germline nuclear … javascript resize image in img tagWeb7 de abr. de 2024 · In addition, the authors predicted that the detected mutations would affect α/β-tubulin heterodimer folding and/or assembly required for meiotic spindle formation. They gave evidence of this hypothesis in experiments in which mutated TUBB8 cRNAs were injected into mouse and human fully-grown immature oocytes. javascript resize image from urlWeb16 de dez. de 2024 · Chk1 depletion does not affect meiotic cell cycle progression after germinal vesicle breakdown and does not cause oocytes to be arrested in the MI stage with abnormal chromosome arrangement, but it decreases the expression of the spindle assembly checkpoint protein Mad2L1 (Mitotic Arrest Deficient 2-Like 1) and the … javascript response objectWeb16 de dez. de 2024 · LRRK2 is mainly accumulated at the meiotic spindle periphery during oocyte maturation. Depleting LRRK2 led to the polar body extrusion defects and also induced large polar bodies in mouse oocytes. javascript resize image base64Web13 de abr. de 2024 · For example, oocyte quality, embryonic development, and fertility can be restored by nicotinamide mononucleotide treatment in aged mice . Germline nuclear transfer, including germinal vesicle, pronuclear, and spindle transfer, is a potential strategy for improving the meiotic competence of aged mouse and human oocytes (93, 94). javascript resize image on uploadWeb28 de mai. de 2024 · In accordance with the mutant oocyte phenotype, we find that EML1 is colocalized with spindle microtubules during the process of normal oocyte meiotic … javascript response string to json