WitrynaThe reaction of hydrazide 4 with β-keto esters 5 gave hydrazones 6 . Cyclization of 6 with Vilsmeier-Haack reagent (DMF-POCl 3 ) for 20 min at room temperature gave 1-(4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carbonyl)-1 H -pyrazole-4-carboxylic acid ethyl esters 7 . The treatment of 4 with substituted acetophenones 8 yielded the corresponding … WitrynaThe 1,5-naphthyridine (1,5-nap) molecule has been elaborated into a series of new bidentate and tridentate ligands using Stille coupling or Friedländer condensation …
Fused 1,5-Naphthyridines: Synthetic Tools and Applications
Witryna18 sty 2024 · Six naphthyridine isomers exist, based on the positions of the nitrogen atoms; they can be in the 1,5, 1,6 (shown here), 1,7, 1,8, 2,6, or 2,7 positions. All are … Witryna1,5-Naphthyridine Melting Point ( C) etc. Reference(s) 2-Acetamido-1,5-naphthyridine 190–192 or 210, NMR 811, 1443 4-Acetamido-1,5-naphthyridine 119–120 814 2-Acetamido-1,5-naphthyridine 1,5-dioxide 230–231 787 4-Acetamido-1,5-naphthyridine 1,5-dioxide 253–254, IR, NMR 814 2-Acetoxymethyl-1,5-naphthyridine 1,5-dioxide … offre switch auchan
Hydrogen-bond-driven dimers of naphthyridine derivatives for …
WitrynaThe 1,8-naphthyridine group of compounds have gained special attention of researchers on account of their demonstrating a variety of interesting biological activities. A wide … WitrynaBackground: Naphthyridine scaffold is an important pharmacophore in compounds which have shown various biological activities like antiviral, antimicrobial, anticancer, antiinflammatory and analgesic. This scaffold is also reported to exhibit activity against HIV, HCMV, HSV, HPV and HCV. Antiviral activity displayed by many naphthyridine … WitrynaA known synthetic approach was used for the preparation of new 3 H -benzo [ b ]pyrazolo [3,4- b]-1,6-naphthyridine derivatives 49 and 50, starting from two ethyl 4-chloro-1 H -pyrazolo [3,4- b ]pyridine-5-carboxylates as the substrates. 15 The reaction conditions and corresponding yields are shown in Scheme 12. offre swisscom ps5