WebJun 19, 2024 · Glutathione peroxidase 4 (GPX4), a selenocysteine enzyme that utilizes glutathione to reduce toxic lipid peroxides into non-toxic lipid alcohols, is critical for the protection against lipid peroxide-mediated damage and ferroptosis induction [ 11 ]. WebApr 7, 2024 · Mounting evidence supports the crucial role of ferroptosis in tumor suppression. For example, a strong dependence of cancer cells on GPX4 and system Xc- has been noted in multiple types of cancer, and the inhibition of the system Xc- coding gene SLC7A11 induces ferroptotic cell death and enhances cytotoxicity in therapy-resistant …
Ferroptosis: A New Promising Target for Lung Cancer Therapy - Hindawi
WebApr 10, 2024 · GPX4 biosynthesis requires selenium and its incorporation into selenocysteine through isopentenylation and selenocysteine tRNA maturation … WebDependency on GPX4 was found to exist across diverse therapy-resistant states characterized by high expression of ZEB1, including epithelial-mesenchymal transition in epithelial-derived carcinomas, TGFβ-mediated therapy-resistance in melanoma, treatment-induced neuroendocrine transdifferentiation in prostate cancer, and sarcomas, which are ... blackmon auction company lancaster
Cells Free Full-Text Ferroptosis Meets Cell–Cell Contacts
WebApr 3, 2024 · -lipid peroxidation activity of intracellular glutathione peroxidase 4 (GPX4). Recent studies have shown that ferroptosis can be involved in the pathological processes of many disorders, such as ischemia–reperfusion injury, nervous system diseases, and blood diseases. However, the specific mechanisms by which ferroptosis participates in the … WebAug 3, 2024 · In this review, we summarize the regulation of the System X c − /GSH/GPX4 axis, a major antioxidant system in ferroptosis, and its potential role in drug-resistant solid tumors therapy, and also conclude with a summary of drugs, compounds and nanoparticles targeting this axis that have been studied in recent years. blackmon auction ar