Fcrg2a
WebMar 21, 2024 · FCGR2C (Fc Gamma Receptor IIc (Gene/Pseudogene)) is a Protein Coding gene. Diseases associated with FCGR2C include Thrombocytopenia Due To Platelet Alloimmunization . Gene Ontology (GO) annotations related to this gene include transmembrane signaling receptor activity and IgG binding . An important paralog of this … WebNov 5, 2015 · The CD32a immunoglobulin G (IgG) receptor (Fcγ receptor IIa) is a potential therapeutic target for diseases in which IgG immune complexes (ICs) mediate inflammation, such as heparin-induced thrombocytopenia, rheumatoid arthritis, and systemic lupus erythematosus. Monoclonal antibodies (mAbs) are a promising strategy for treating such …
Fcrg2a
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WebApr 10, 2024 · The FCGR2a receptor was genotyped for each sample, and RNA-seq was performed on isolated, leukocyte-depleted platelets. Transcriptomic data were used to create a modular landscape to explore the differences between SLE patients and controls and various clinical parameters in the context of FCGR2a genotypes. WebApr 10, 2024 · The FCGR2A rs1801274 (A > G) SNP gives rise to a replacement of histidine (His) by arginine (Arg) (His131Arg) [67,68]. Previous studies on other diseases have shown that FCGR2A with His instead of Arg at position 131 resulted in a higher affinity for IgG1 [ 69 ], which may explain the association of the G allele with response.
WebNov 5, 2015 · The CD32a immunoglobulin G (IgG) receptor (Fcγ receptor IIa) is a potential therapeutic target for diseases in which IgG immune complexes (ICs) mediate inflammation, such as heparin-induced thrombocytopenia, rheumatoid arthritis, and systemic lupus erythematosus. Monoclonal antibodies (mAbs) are a promising strategy for treating such …
WebMar 21, 2024 · FCGR2A (Fc Gamma Receptor IIa) is a Protein Coding gene. Diseases associated with FCGR2A include Cystic Fibrosis and Systemic Lupus Erythematosus . … WebDec 17, 2024 · The expression of FcγRIIA by human platelets, which is their unique receptor for immunoglobulin G antibodies, positions them to ideally respond to circulating ICs. Whereas chronic platelet activation and thrombosis are well-recognized features of human SLE, the exact mechanisms underlying platelet activation in SLE remain unknown.
WebFCGR2A is a cell surface receptor that was formerly known as CD32. The gene locus is at 1q23; the gene product is expressed on a wide variety of cell types, and it mediates multiple cell-type specific functions including phagocytosis, release of inflammatory mediators, and clearance of immune complexes (76).
WebFCGR2A Addgene Alerts Receive email alerts when new plasmids with this gene become available. Log in to subscribe to Addgene Alerts. Description Fc gamma receptor IIa Also known as CD32, CD32A, CDw32, FCG2, FCGR2, FCGR2A1, FcGR, FcgammaRIIa, IGFR2 Species Homo sapiens Entrez ID 2212 MGC ID BC019931, BC020823 smart dev downloadWebAug 1, 2010 · The FcγRI is a high-affinity receptor that mainly binds monomeric IgG, while FcγRII and FcγRIII interact preferentially with immune complexes 4, 5, 6, 7. Following ligand binding, FcγRI, FcγRIIa, and FcγRIII are activating receptors while FcγRIIb is the only inhibitory receptor. hilleyhttp://www.cancerindex.org/geneweb//FCGR2A.htm smart device 2000 tsp-lgts021WebSystematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease Systematic identification of genomic elements that regulate FCGR2A expression and harbor variants linked with autoimmune disease Authors hilley \\u0026 solis lawWebApr 7, 2024 · The FCGR2a receptor was genotyped for each sample, and RNA-seq was performed on isolated, leukocyte-depleted platelets. Transcriptomic data were used to create a modular landscape to explore the differences between SLE patients and controls and various clinical parameters in the context of FCGR2a genotypes. There were 2290 … smart device connectivity hillromWebFc gamma RIIA is expressed on many immune cell types (macrophage, neutrophil, eosinophils, platelets, dendritic cells and Langerhan cells) where inhibitory ITIM-bearing … smart deviation loginWebImmunoglobulin G (IgG) antibodies are important for protection against pathogens and exert effector functions through binding to IgG-Fc receptors (FcγRs) on myeloid and natural killer cells, resulting in destruction of opsonized target cells. hilley and solis