Destabilization of medial meniscus
WebFeb 9, 2024 · Age is the primary risk factor for osteoarthritis (OA), yet surgical OA mouse models such as destabilization of the medial meniscus (DMM) used for evaluating … WebIn the µCT analysis, destruction of the medial tibial plateau was observed in 4/40 knees, while none were observed in the DMM group. Of the four knees, destruction of the …
Destabilization of medial meniscus
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WebJun 28, 2024 · A mouse OA model was induced using destabilization of the medial meniscus (DMM) surgery, chondrocyte ferroptosis was induced using an intra-articular injection of Erastin, and Met (200 mg/kg/day) was intragastrically administered for 8 weeks after surgery. H&E and Safranin O‑fast green staining were used to evaluate cartilage … WebJan 1, 2015 · Destabilization of the medial meniscus (DMM) surgery and tissue processing post-DMM. DMM surgeries were performed, as described 32, 33 , in 12-week-old male IKKα cKO and WT littermates. Power...
WebFeb 12, 2024 · The DMM (destabilization of the medial meniscus) model is now the most commonly used surgical model in mice. Its reliability, reproducibility, structural similarity to human OA, its relatively... WebSep 29, 2024 · Destabilization of the medial meniscus (DMM) is commonly used as a surgical model of OA in the mouse . In this model transection of the mediomeniscotibial ligament (MMTL) results in a slowly progressing …
WebNov 11, 2024 · Mice subjected to surgery for destabilization of the medial meniscus (OA group) or control surgery (Control group) were sacrificed after eight weeks. The knees were collected for histological assessment. WebApr 6, 2024 · Tryptase β regulation of joint lubrication and inflammation via proteoglycan-4 in osteoarthritis - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil.
WebExperimental OA was induced in 12-week-old male mice (C57BL/6J) by destabilization of the medial meniscus (DMM) surgery as described by Glasson et al. . The medial meniscus tibial ligament was exposed without sectioning in sham surgery. Mice were sacrificed 8 weeks after DMM or sham surgery and subjected to histological analyses.
WebMar 4, 2024 · This is much more severe than a standard degenerative meniscus tear that may have a flap or piece that is torn, but the majority of the meniscus is intact. Instead, the meniscus root tear affects the … blais google scholarWebApr 10, 2024 · Methods: In the present study, C57BL/6J mice were divided into the following three groups: the sham control, destabilization of the medial meniscus (DMM), and AMD3100-treated DMM (DMM + AMD3100) groups. The mice were sacrificed after 2 or 8 weeks, and samples were collected for histological and immunohistochemical analyses. … fractal it self serviceWebApr 1, 2024 · Methods Destabilization of the medial meniscus (DMM) or sham surgeries were performed on 10-week-old male wild-type (WT) and Camkk2-/- mice. Half of the DMM-WT mice and all other cohorts ... fractal is jobsWebDesign: Acomys received destabilization of the medial meniscus (DMM) surgery (n = 11) or a skin incision (n = 10). Gait testing occurred at 4, 6, 8, 10, and 12 weeks after surgery. At endpoint, joints were processed for histology to assess cartilage damage. Results: Following joint injury, Acomys with DMM surgery altered their walking patterns ... fractal industryWebDestabilization of the medial meniscus (DMM) was performed on the right knees of 2 month-old male Matn1-/- (n = 11) and Matn1+/+ (n = 9) mice. A) mRNA levels of type II collagen (Col2a1) and... blais flowers \\u0026 garden center lewiston meWebInduction of DMM: Animals (mice or rats) are anesthetized with Isoflurane and the right knee area and lower leg are prepared for surgery. For the surgical destabilization of the medial meniscus (DMM), a skin incision … blais in frenchWebApr 7, 2024 · 按文献方法采用内侧半月板失稳(destabilization of medial meniscus，DMM)手术诱导建立KOA模型[9]，简述如下：右膝关节内侧髌韧带与内侧副韧带之间开0.5 cm切口，显微镜下暴露、剪断内侧半月板胫骨韧带，缝合切口。 fractal hearts