2024 Cisplatin mouse

Cisplatin mouse

Author: jmop

August undefined, 2024

WebSep 2, 2024 · Animals and Experimental Models. C57BL/6 mice (male, aged 8 weeks) were obtained from the Animal Core Facility of Nanjing Medical University. They were housed individually in cages under hygienic conditions and placed at a constant room temperature (23 ± 1°C) and humidity (30–40%) and maintained in a 12-h light/dark cycle room with … WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine monophosphate …

Cisplatin (NSC 119875) ≥99%(HPLC) - selleckchem

Webstudies in mice and rats, cisplatin acted as a tumor initiator follow-ing transplacental exposure via a single intraperitoneal injection late in gestation. In mice, transplacental … Webcisplatin can be used to cause renal dysfunction as an approach to mimic human serum levels of renally excreted drugs. We aimed to determine the dose of cisplatin that did … la jota alquiler

The protective effects of maltol on cisplatin-induced

WebMay 11, 2012 · Mice were given LPs-pVAX or LPs-pVAX-LKB1 complexes by intratumoral injection at a dose of 20 μg per mice and/or low-dose cisplatin (2 mg kg −1 per mice) by i.p injection. After 24 h of the ... WebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... Thus, … WebDec 2, 2024 · In the animal model, C57 mice were given weekly injection of 8 mg/kg cisplatin for 4 wk. This led to a sustained decline of kidney function. These mice showed loss of kidney mass, interstitial fibrosis, continued activation of inflammatory cytokines, and appearance of atubular glomeruli. lajota antiga

Enhanced antitumor effect of cisplatin in human NSCLC cells by …

Granulocyte-colony stimulating factor does not prevent in vitro ...

WebOct 1, 2024 · Cisplatin, the most widely used platinum-based anticancer drug, often causes progressive and irreversible sensorineural hearing loss in cancer patients. However, the precise mechanism underlying cisplatin-associated ototoxicity is still unclear. Nicotinamide adenine dinucleotide (NAD+), a … WebOct 1, 2024 · Developing better mouse models to study cisplatin-induced kidney injury Cisplatin-Induced AKI in the Clinical Setting. Although it is a potent choice for first-line … la jota aragonesa youtubeWebJul 4, 2024 · Cisplatin administered on the day of wounding decreased tumor burden by 50%, as compared to 90% in unwounded animals. Cisplatin on day 7 or day 28 decreased tumor burden by 80 and 37% respectively. Conclusions Surgical wounding increases ovarian tumor mass and decreases perioperative cisplatin efficacy in this animal model. lajota ardosia

"WebWe recently reported that human and mouse cells containing an African-specific coding region variant of p53, Pro47Ser (hereafter S47), are impaired in the transactivation of a small subset of p53 ... " - Cisplatin mouse

Cisplatin mouse

Modulation of NAD+ biosynthesis activates SIRT1 and resists cisplatin ...

WebAntitumor efficacy of aptamer‐siRNA nano‐zinc carriers in a mouse lung cancer model bearing A549/DDP cells. A549/DDP or A549 cells were implanted subcutaneously in nude mice. After 10 days, mice received a single intravenous injection of 5 mg/kg/d A10/NaZ/siUSP14#1 followed by serial fluorescence imaging at the indicated time points. WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different …

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WebFeb 18, 2024 · C57BL/6 mice were intraperitoneally injected with cisplatin (15 mg/kg) and then sacrificed at 8, 12, 24, and 72 h. A The body weight decreased 8–72 h after cisplatin treatment ( n = 4). B... WebCisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar …

WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney … WebAug 17, 2024 · Cisplatin (cis-Diaminodichloroplatinum, CDDP), one of the most potent chemotherapeutic agents, has been proven effective against various solid tumors, including sarcoma, soft tissue cancer, bone cancer, muscle cancer, and vascular cancer.

WebCisplatin-nephropathy model mice exhibited elevated levels of serum IS accompanied by elevated levels of blood urea nitrogen and serum creatinine. Furthermore, intraperitoneal administration of IS in mice promoted tumor growth and metastasis. Finally, we found that the MasR agonist Ang-(1-7) suppressed the IS-mediated effects on cell ... WebOct 7, 2024 · Abstract 1. Introduction In 2024, 18.1 million new cases and 9.5 million cancer-related deaths were diagnosed worldwide. It is... 2. Cisplatin Mouse Models Cisplatin …

WebDec 5, 2024 · Cisplatin also induces PD-L1 in tumor cells, suggesting dichotomous roles and supporting the need for combination with PD …

WebApr 14, 2024 · The investigations demonstrated different impacts of cisplatin on CTR1 expression on the single-cell level according to the resistance status. The study showed this interrelation for the first time at the single-cell level. It could be shown in this study that the resistant ovarian cancer cells as compared to the sensitive cells are ... la jota baileWebOur previous studies indicated that cisplatin administration to mice caused muscle atrophy. This is a concern for human patients receiving cisplatin. The insulin-like growth factor 1 (IGF-1)/phosphoinositide 3-kinase (PI3K)/Akt pathway stimulates the rate of protein synthesis in skeletal muscle. la jota aragonaiseWebCisplatin can cause fetal harm when administered to a pregnant woman. Cisplatin is mutagenic in bacteria and produces chromosome aberrations in animal cells in tissue culture. In mice cisplatin is teratogenic and embryotoxic. If this drug is used during pregnancy or if the patient becomes la jota balonmanoWebMar 16, 2024 · Cisplatin is an alkylating-like platinum-based chemotherapeutic drug commonly used in paediatric oncology [ 5 ]. The understanding of how exposure to cisplatin affects the future fertility of pre-pubertal boys predominantly comes from retrospective follow-up studies [ 6 ]. la jota baile historiaWebAbstract Cisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. ... Thus, mice bearing A549/DDP cells were sacrificed and the organs were excised for ex vivo imaging. Ex vivo fluorescent imaging showed a strong signal in tumors, heart, liver, ... la jota en cursiva mayusculaWebSep 1, 2024 · First, we examined whether cisplatin altered renal iron levels and induced oxidative stress in mice. Cisplatin increased the production of ferrous iron and hydroxyl radical, and they were colocalized in the kidney, suggesting the occurrence of the Fenton reaction ( Fig. 1 A–C). la jota castellanaWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … lajota eps