WebFeb 18, 2024 · Chloramphenicol (CAP) as a broad-spectrum antibiotic is commonly used as a human antibiotic and veterinary drug due to its low cost and excellent antibacterial effects against many Gram-positive and Gram-negative bacteria [1,2].However, CAP has many dangerous side-effects, including aplastic anaemia, genotoxic carcinogenicity and … Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever. Its use by mouth or by injection is only recommended when … See more The original indication of chloramphenicol was in the treatment of typhoid, but the presence of multiple drug-resistant Salmonella Typhi has meant it is seldom used for this indication except when the organism is known … See more Chloramphenicol is extremely lipid-soluble; it remains relatively unbound to protein and is a small molecule. It has a large apparent volume of distribution and penetrates … See more Chloramphenicol was first isolated from Streptomyces venezuelae in 1947 and in 1949 a team of scientists at Parke-Davis including Mildred Rebstock published their identification of the chemical structure and their synthesis. In 1972, Senator See more Although its use in veterinary medicine is highly restricted, chloramphenicol still has some important veterinary uses. It is currently considered the most useful treatment of … See more Aplastic anemia The most serious side effect of chloramphenicol treatment is aplastic anaemia. This effect is rare but sometimes fatal. The risk of AA … See more Chloramphenicol is a bacteriostatic agent, inhibiting protein synthesis. It prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome. … See more Names Chloramphenicol is available as a generic worldwide under many brandnames and also under various generic names in eastern Europe and … See more

Chloramphenicol - an overview ScienceDirect Topics

WebChloramphenicol should only be used for serious infections in which other medicines do not work. This medicine may cause some serious side effects, including blood problems … WebChloramphenicol is a Type 3 compound (see Chapter 1.10). This compound, discovered in 1947 from a fermentation broth of Streptomyces venezuelae, possesses two asymmetric … faber children\\u0027s classics

Pharmacokinetic and toxicological aspects of the medication of …

WebChloramphenicol is a broad spectrum antibiotic that is active against both gram-positive and gram-negative bacteria.. However, due to its severe toxicity, chloramphenicol is no longer used as the first medication of choice in most countries with access to safer antibiotics; instead, this medication is typically used when other antibiotics are ineffective … WebDescription: Chloramphenicol inhibits bacterial protein synthesis by binding to 50S subunit of the bacterial ribosome, thus preventing amino acid transfer to growing peptide chains thereby inhibiting protein synthesis. … WebChloramphenicol (3399) Chloramphenicol and ampicillin (1423) Chloramphenicol and bleocin (zeocin) (9) Chloramphenicol and gentamicin (24) Chloramphenicol and … does honey work on scorptec